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Vanadyl
Sulfate:
Trace
mineral which works like insulin to increase the amount of glucose and
amino acids driven into the muscle. Vanadyl Sulfate is a
compound of Vanadium, Sulfur, and Oxygen.
Vanadium:
Mineral element found naturally in some food and
the human
body that helps to
balance blood sugar levels and aids in the release of energy.
Food sources rich in Vanadium
 eggs
black pepper
dill seed
parsley
olives
olive oil
sunflower oil
apples
buckwheat
oats
shellfish
radishes
mushrooms
soy
corn
Studies have shown both positive and negative health effects of
Vanadium and Vanadyl
Sulfate.
Example of positive
health effects:
Vanadyl
sulfate improves hepatic and
muscle insulin sensitivity in type 2 diabetes
Source: J
Clin Endocrinol Metab. 2001 Mar;86(3):1410-7.
According to a study performed by the University
of
Texas Health Science Center, San Antonio, Texas in 2001, Vanadyl
Sulfate was shown to
reduce hyperglycemia, improved liver and muscle insulin
sensitivity, and
significantly improved glycemic control
in a small study of (11) people with type 2 diabetes. Another
benefit was that
Vanadyl
Sulfate reduced cholesterol levels (including LDL cholesterol)
in the
patients.
Abstract of the study:
University
of Texas Health Science Center, San Antonio, Texas 78284, USA.
cusi@uthscsa.edu
Vanadyl
sulfate (VOSO(4)) is an oxidative form of vanadium that in vitro and in
animal models of diabetes has been shown to reduce hyperglycemia and
insulin resistance. Small clinical studies of 2- to 4-week duration in
type 2 diabetes (T2DM) have led to inconsistent results. To define its
efficacy and mechanism of action, 11 type 2 diabetic patients were
treated with VOSO(4) at a higher dose (150 mg/day) and for a longer
period of time (6 weeks) than in previous studies. Before and after
treatment we measured insulin secretion during an oral glucose
tolerance test, and endogenous glucose production (EGP) and whole body
insulin-mediated glucose disposal using the euglycemic insulin clamp
technique combined [3-(3)H]glucose infusion. Treatment significantly
improved glycemic control: fasting plasma glucose (FPG) decreased from
194 +/- 16 to 155 +/- 15 mg/dL, hemoglobin A(1c) decreased from 8.1 +/-
0.4 to 7.6 +/- 0.4%, and fructosamine decreased from 348 +/- 26 to 293
+/- 12 micromol/L (all P < 0.01) without any change in body
weight.
Diabetics had an increased rate of EGP compared with nondiabetic
controls (4.1 +/- 0.2 vs. 2.7 +/- 0.2 mg/kg lean body mass.min;
P<
0.001), which was closely correlated with FPG (r = 0.56; P<
0.006).
Vanadyl sulfate reduced EGP by about 20% (P< 0.01), and the
decline
in EGP was correlated with the reduction in FPG (r = 0.60; P<
0.05).
Vanadyl sulfate also caused a modest increase in insulin-mediated
glucose disposal (from 4.3 +/- 0.4 to 5.1 +/- 0.6 mg/kg lean body mass
x min; P< 0.03), although the improvement in insulin sensitivity
did
not correlate with the decline in FPG after treatment (r = -0.16; P =
NS). Vanadyl sulfate treatment lowered the plasma total cholesterol
(223 +/- 14 vs. 202 +/- 16 mg/dL; P < 0.01) and low density
lipoprotein cholesterol (141 +/- 14 vs. 129 +/- 14 mg/dL; P <
0.05),
whereas 24-h ambulatory blood pressure was unaltered. We conclude that
VOSO(4) at maximal tolerated doses for 6 weeks improves hepatic and
muscle insulin sensitivity in T2DM. The glucose-lowering effect of
VOSO(4) correlated well with the reduction in EGP, but not with
insulin-mediated glucose disposal, suggesting that liver, rather than
muscle, is the primary target of VOSO(4) action at therapeutic doses in
T2DM.
Example of negative
health effects:
Effect of Vanadium on Insulin Sensitivity in Patients
with Impaired Glucose Tolerance
Source: Ann Nutr Metab. 2008 Nov 22;53(3):195-198
This study showed that Vanadyl
Sulfate caused triglyceride levels to go up
when given to 14 overweight
and obese people with impaired glucose tolerance. Triglyceride levels
going up is undesirable,
since high triglycerides alone can increase your risk of
cardiovascular disease. [According to Mayo
Clinic.] The 14 people in this study
did not see
any improvement in insulin sensitivity either. This small
study suggests that Vanadium is not a good choice for overweight or
obese people that already have impaired glucose tolerance.
Abstract of the study:
Jacques-Camarena
O, González-Ortiz M, Martínez-Abundis E, López-Madrueño JF,
Medina-Santillán R.
Medical
Research Unit in Clinical Epidemiology, Medical Unit of High Specialty,
West National Medical Center, Mexican Institute of Social Security,
Guadalajara, Mexico.
Background/Aim:
Impaired glucose tolerance (IGT) is considered a risk factor for
developing type 2 diabetes mellitus (T2DM) and is associated with
insulin resistance. Vanadium seems to block protein tyrosine
phosphatase with the consequent increment in insulin sensitivity (INS)
in T2DM patients, but this effect has not been studied in IGT patients.
The aim of this study was to evaluate the effect of vanadium on INS in
IGT patients. Methods: A randomized, double-blind, placebo-controlled
clinical trial was carried out in 14 overweight/obese patients with
IGT. Intervention consisted of vanadyl sulfate (VS, 50 mg p.o. twice
daily) or placebo for 4 weeks. Before and after the intervention, a
metabolic profile was performed and INS was assessed using the
euglycemic-hyperinsulinemic clamp technique. Mann-Whitney U and
Wilcoxon rank tests were used for statistical analyses. Results: There
were no significant differences in basal characteristics between
groups. VS did not affect INS [2.7 +/- 0.8 vs. 2.9 +/- 0.9 mg/(kg/min),
p = 0.735] but increased triglyceride levels (1.35 +/- 0.61 vs. 1.70
+/- 0.46 mmol/l, p = 0.018). Conclusions: VS administration in IGT
patients increased triglyceride concentrations without changes in INS.
Copyright © 2008 S. Karger AG, Basel.
In the future, stem cells may be used to help patients
with type 1 diabetes gain insulin independence. Details are in the
video below.
Page last edited by Earl, Apr-21-2009
Comments
cab -
Monday, September 4, 2006 at 19:42
I worked for a Holistic Doctor for 2 1/2 years . He had me on Vanadium
from a company called nutra west . I was taking 3 to 4 pills a day . It
really kept my sugar from getting high . Sense he died , I can't find a
Doctor that sales this . I have tried other products , But they don't
seem to work as good .
liz - Saturday,
January 27, 2007 at 21:52
if you do find where you can get it please, please can you share it.
thank you
louise hartman - Wednesday,
January 23, 2008 at 06:52:44
I would like to know where I can get vanadium. I have seen it on the
internet, but do not know here to get it. I live in Charlotte N.C.
Chuck -
Friday, February 08, 2008 7:10 PM
I am taking 5000 mcg daily ( 1capsule) of vanadyl
sulfate to help control my blood sugar. What would be your recommended
dosage? I am type two diabetic. Your input would be most appreciated.
Tks.
sandra
- Friday, February 22, 2008 at 09:34
I used to purchase Vanadyl sulfate from Olympian Labs
but they no longer carry it. Where can I purchase some now? thank you
sandra
-
Saturday, March 15, 2008 at 11:29
Vitamin
world carries vanadyl
sulfate in there catalog
or order on line
Carlos - Monday,
September 8, 2008 at 10:12 PM
You can find vanadyl
or vanadium from Puritan
Pride
Vitamins on-line......
Larry - Monday,
March 16, 2009 at 02:12 AM
You can find Vanadium
from Swanson for about $3.49 for 60 caplets, they even put it in some
of their multiple vitimins.
Earl - Monday, March 16, 2009 at 11:17 AM
I decided to let visitors add links to online stores that sell
Vanadyl Sulfate or Vanadium. I went back through the comments
above and added links to the sources that visitors found. If you
know of more sources where you can buy these products, you may add them here in the comments.
Thanks.
James - Wednesday, May 20, 2009 at 8:30 PM
Vanadyl Sulfate 5000 mcg (micro grams), 180 capsules, can be purchased from
Super Supplements for approximately $9.
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